Shaun Marsh will captain the team in the absence of Aaron Finch who has been granted leave following an extended period in various hubs across the globe.
Finch will be available for the Renegades next match on December 26.
Internationals Mohammad Nabi and Noor Ahmad have been included in the squad for the first time this season following the completion of their quarantine period.
Benny Howell, who was an Overseas Replacement Player for Nabi, is now unavailable for selection.
Will Sutherland returns to the Renegades squad after representing Australia A last week. Peter Hatzoglou was a Local Replacement Player for Sutherland, but remains eligible for selection as he is now a Local Replacement Player for James Pattinson who is in the Australian Test squad.
The match will be broadcast LIVE on Channel 7 and Fox Cricket from 11:10am.
Hobart Hurricanes v Melbourne Renegades
Saturday December 19
Blundstone Arena, 11:10am
Melbourne Renegades Squad
Shaun Marsh (captain)
Brody Couch (Local Replacement Player for Marcus Harris)
Peter Hatzoglou (Local Replacement Player for James Pattinson)
Mohammad Nabi (AFG)
Noor Ahmad (AFG - Overseas Replacement Player for Imran Tahir)
Rilee Rossouw (RSA)