Cameron Boyce, Usman Khan Shinwari, Will Sutherland and Dan Christian are in line to play their first games for the club.
Sam Harper and Kelvin Smith have been added to the Renegades squad and could also make their club debuts.
The pair have been elevated in place of Aaron Finch (Harper) who is on national duties and Mackenzie Harvey (Smith) who is injured.
Harper is a wicket-keeper/batsman who has impressed in recent Renegades trial matches and Smith is a batsman from South Australia with previous BBL experience.
Tom Cooper will lead the side in the absence of Finch.
The final XI will be named at the 'bat flip'.
The match will feature two performances from leading FMX riders and the launch of The Woolworths Slide.
For all your FMXmas match day information, please click here.
Melbourne Renegades v Perth Scorchers
Thursday December 20
Tom Cooper (Captain)
Dan Christian (Vice Captain)
Usman Khan Shinwari