Beau Webster, Chris Tremain and Jon Holland all come into the squad for the trip to Sydney. The trio replaces Joe Mennie, Jack Wildermuth and Marcus Harris who has departed for Australian Test team duties in Brisbane.
Holland captured 4-28 in the second innings of the Cricket Australia XI's match against Sri Lanka last week in Hobart.
The Renegades are in third spot on the ladder ahead of the clash with the fourth placed Thunder.
Sydney Thunder v Melbourne Renegades
Tuesday January 22
Aaron Finch (Captain)