Aussie T20 World Cup heroes Sophie Molineux, Georgia Wareham and Tayla Vlaeminck have been selected in the squad to take on Sydney Thunder at the CitiPower Centre on Sunday.
Should Vlaeminck be selected in the final XI this weekend, she will be making her Renegades debut.
International recruit Danni Wyatt was ruled out of the match by the England Cricket Board following the T20 World Cup, but she will available for the Renegades next match.
Don't miss the important GAME DAY INFO
Amy Satterthwaite will again lead the side as the Renegades begin the push for their first Big Bash finals appearance.
The Big Weekend features all eight WBBL teams playing at Cricket Victoria’s newly-refurbished CitiPower Centre at the Junction Oval in St Kilda.
Sunday 2 December
Melbourne Renegades v Sydney Thunder
CitiPower Centre, 1.50pm
Squad vs Sydney Thunder
Amy Satterthwaite (C)