It was a dominant performance from the Stars, who recorded a six-wicket win inside the 15th over.
The Renegades won the bat flip and elected to bat first, but it was more of the same after their recent woes with the bat.
Shaun Marsh and Nic Maddinson both fell within the power play, and Mackenzie Harvey not long after, as the hosts stumbled to 3-25.
Aaron Finch - who came in at number five - led a slow but steady rebuild with Jake Fraser-McGurk.
At the midway mark, the Renegades had 3-53 on the board.
Finch and Fraser-McGurk put together a 51-run partnership, before the latter was deceived by Qais Ahmad.
They remained as the only Renegades at the end of the innings to reach double figures.
Finch scored 45 off 44 deliveries, including three fours and the Renegades' lone six, with Fraser-McGurk managing 32 from 39.
After finishing with 7-122, the Renegades were in desperate need of early wickets.
Joshua Lalor struck in the first over to remove Joe Clarke, before Zahir Khan rattled the stumps of Beau Webster in the second.
But Glenn Maxwell steadied the ship and finished the run chase unbeaten on 68 from 45 deliveries.
The Renegades finished with four wickets - Cameron Boyce and Kane Richardson also claiming one apiece.
But they couldn't prevent the Stars from rattling to their total with 33 balls remaining.
The result leaves the Renegades at the bottom of the BBL|11 table, with two games remaining in the tournament.
They will face the Hobart Hurricanes on Tuesday at Marvel Stadium, followed by the Sydney Thunder on Wednesday at the MCG.