It was an off-day for the Renegades, who struggled to make inroads with the ball and then couldn't get things rolling in their run chase.
Skipper Sophie Molineux won the toss, elected to bowl and picked up the key wicket of Rachel Priest with her second delivery.
But from there, it was a tough afternoon at the office for the Renegades.
Ruth Johnston (63) and Mignon du Preez (50) combined for a 120-run stand to set up the game for the Hurricanes.
The Renegades fought back late with the ball, pulling the Hurricanes back to 5-161 off their 20 overs.
Molineux was the pick of the bowlers in her 85th game in red - equalling Molly Strano's games record at the Renegades.
The left-arm spinner finished with 1-12 off her four overs.
Courtney Webb returned from injury and picked up 2-27 from her four overs, while Harmanpreet Kaur also claimed two wickets.
In reply, the Renegades lost Eve Jones early, but responded to be 1-42 after the power play.
From there though, they lost wickets at regular intervals. Ellie Falconer finished as the team's top scorer, with an unbeaten 24 off just 12 deliveries - including three sixes.
Jemimah Rodrigues (19), Jess Duffin (17) and Webb (14) were the only other batters to reach double figures.
With top spot still up for grabs, the Renegades will be desperate to turn things around quickly - they will face the Brisbane Heat in Mackay tomorrow night.