With bat and ball, the Renegades found their groove and got home by five wickets with five overs to spare against a Heat outfit missing 12 first-choice players.
Skipper Nic Maddinson won the toss and elected to send the Heat in.
Zak Evans came into the side for his first game of BBL|11 and James Pattinson returned after receiving a negative COVID test.
Spin did the damage early, as Zahir Khan claimed two wickets in the first 10 overs to help restrict the Heat to 2-58 at the midway point of their innings.
Mohammad Nabi was subbed into the game for Pattinson after 10 overs and made an immediate impact with a wicket.
He finished with 2-19 from his four overs, including conceding just two runs off the final over to keep the Heat to 6-128.
Zahir also impressed with 2-21, while Kane Richardson was his usual, dependable self with figures of 2-22 – becoming the BBL’s second-highest wicket-taker in the process.
With the bat, the Renegades lost Sam Harper in the first over but made quick work of their chase.
Shaun Marsh, in his second game back from a calf injury, was at his brilliant best with 57 from just 35 deliveries.
His innings featured three sixes and six fours, putting the game beyond doubt before being caught in the deep.
Aaron Finch cleared the rope twice in his innings of 37 from 28 balls, before he too was caught on the boundary trying for a third.
Despite a couple of late wickets, an unbeaten 22 from Maddinson helped guide the Renegades to their total.
After back-to-back wins, the Renegades will again play at home on Saturday – this time at Marvel Stadium – against the Sydney Thunder.