The Thunder raced out of the blocks, with Englishman Alex Hales (44 off 22) and Aussie Test hero Usman Khawaja (77 off 51) combining for an 80-run partnership.
It was Cameron Boyce’s innings however, with the leg-spinner claiming a double hat-trick and a five-wicket haul, ending with sensational figures of 5-21.
Boyce was able to break the opening stand of Hales and Khawaja, with Hales holding out to deep mid-off.
Boyce then went on a rampage, catching Jason Sangha out of his crease with a lovely, flighted delivery, and claiming two lbws in consecutive deliveries.
Everything Boyce touched turned to gold, as he was able to run out Ben Cutting with his fingertips off his own bowling.
Zak Evans and Josh Lalor picked up one wicket apiece at the death, as the Thunder managed to post 8-170.
The Renegades then went to work with the bat, with Aaron Finch continuing his outstanding vein of form, hitting 82 runs from 64 balls.
Finch was joined by Indian Unmukt Chand (29 off 22) for an impressive 68-run partnership.
Requiring 47 runs off 30 balls, Jono Merlo (15 off 9) came to the crease and showed off some expansive and effective stroke play.
However, late wickets for the Thunder clawed back momentum.
When Will Sutherland arrived out in the middle, nine runs were required from three balls.
Sutherland heaved a massive six, swinging back momentum in the Renegades favour.
Two runs were needed off the last ball, as Gurinder Sandhu held his nerve to see the Thunder edge out the Renegades by a run.