Fast bowler Chris Tremain replaces Will Sutherland in the 13-man squad.
The undefeated Renegades will be looking for their third straight win of the campaign, while the Scorchers have also been impressive in their opening two outings.
The match will feature entertainment from the Freestyle Motocross riders that have become synonymous with Melbourne Renegades matches.
Entertainment starts from 6:30pm.
Melbourne Renegades squad v Perth Scorchers
Friday December 29
Aaron Finch (Captain)