The Renegades have split the season series with the Stars after falling to a 46-run defeat at Etihad Stadium on Saturday.
Chasing a mammoth 201 for victory, the Renegades were off to a flying start with opening pair Aaron Finch and Sunil Narine going at the required asking rate.
However the departure of the duo in the same over off the bowling of Scott Boland put a brake on the run rate, and the Renegades never really recovered.
Cameron White’s 37 was the top score, but wickets constantly fell around him and momentum stayed firmly on the Stars’ side.
Some late hitting from Chris Tremain helped salvage part of the Renegades’ net run rate, but the final margin was a 46-run defeat.
Earlier James Pattinson marked his comeback by taking the wicket of Luke Wright in his first over, but the returning Rob Quiney quickly stole any Renegades momentum.
Quiney’s 51 off only 30 deliveries included six boundaries and three sixes, part of a 66-run partnership with Kevin Pietersen.
The left-hander’s dismissal paved the way for Pietersen to take over, and he proceeded to play one of his best innings for the Stars, making a brilliant 73.
Quickfire innings from Glenn Maxwell (24 off 17) and David Hussey (27 off 11) propelled the Stars to their total of 7/200, which proved too much for the Renegades in front of a crowd of 44,189.
The Renegades, now at two wins and two losses, travel to Sydney for a matchup against the Sixers on Monday evening.